Proton Mrs of Hepatic Ischemia/reperfusion Injury in an Experimental Rat Model

INTRODUCTION Hepatic ischemia/reperfusion injury (IRI) occurs during liver transplantation, tumor resection, hemorrhagic shock and veno-occlusive disease, and is a major cause of acute liver failure which associated with high morbidity and mortality. IRI in liver is also responsible for early organ failure and increased incidence of both acute and chronic rejection after liver transplantation. Biochemical changes caused by hepatic IRI lead to hepatocellular remodeling, including cellular regeneration or irreversible programmed cell death. Proton magnetic resonance spectroscopy (H MRS) has been increasingly employed to investigate in vivo liver metabolism noninvasively. However, in vivo study of hepatic IRI model using such technique has been limited. In this study, we aim to demonstrate that the alterations in the liver metabolism can be monitored with H MRS using an experimental hepatic IRI model in rats at 7 T.